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Dendritic Cell Protocols
Description
It
is now apparent that dendritic cells not only play important roles in
the body's immune system through their complex interactions with T
cells, B cells, and other cell types, but also possess distinct
functional attributes that enable them to assume different roles in
that system. In Dendritic Cell Protocols, Stephen P. Robinson, MD,
PhD, and Andrew Stagg, PhD, have brought together a wide range of
time-proven methods for studying these so-called "veiled"
cells. Many of these readily reproducible techniques deal with the
problem of obtaining sufficient dendritic cells for analysis, whether
by isolation from a wide variety of tissues or from various
progenitor cell populations. Other methods describe in step-by-step
fashion the techniques commonly used for analyzing aspects of
dendritic cells, ranging from cell migration to antigen uptake and T
cell stimulation. Variant methods that have been successful in other
laboratories have been included to expand experimental possibilities.
In addition, a few techniques explore the practical challenges
involved in using dendritic cells in a clinical setting to develop
novel immunotherapeutics.
State-of-the-art and highly
practical, Dendritic Cell Protocols provides both experienced and
novice investigators with powerful tools to illuminate the complex
biology of these foundation cells-cells that shape the evolution of
acquired immune responses, play important roles in innate immunity,
and promise the development of powerful new immunotherapeutics.
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